Cedric PEIRS

NEURO-DOL - UMR1107 INSERM/UCA
2, rue de Braga
63100
Clermont-Ferrand
FRANCE

63001 Clermont-Ferrand
France

a-marie.gaydier@uca.fr

Dr. Cedric PEIRS

Principal Investigator
TEAM 2 (R. DALLEL), TEAM 2 - Mechanical pain

cedric.peirs@-Code to remove to avoid SPAM-inserm.fr
+33(0)4-7317-7311, room 245

Students :

Alice GILBERT
Anais LEGRAND

My research focusses on the neurobiology of pain, especially the neuronal circuitry of the spinal cord and medullary dorsal horns underlying chronic pain. I received a M.Sc. at the University of Bordeaux (France) and a Ph.D. in Neuroscience at the University of Auvergne (France). I did a postdoctoral training first with Dr. Rebecca Seal at the University of Pittsburgh (USA) and then with Pr. Radhouane Dallel at the University Clermont-Auvergne (France). I became a full researcher at the National Institute of Health and Medical Research (Inserm) in 2018.

Major contributions include 1) the investigation of the segmental circuit underlying static mechanical allodynia using the capsaicin pain model, 2) the identification of a cellular mechanism responsible for the disinhibition of PKCγ neurons by recative oxygen species (ROS) that leads to the transformation of touch into pain, 3) the identification of several neuronal populations that participate in the persistent pain network and 4) the concept that multiple spinal microcircuits encode mechanical hypersensitivity with their own signature role in facilitating the pain depending on the type of insult. Currently, we combine opto/pharmacogenetics, behavior analysis, patch-clamp electrophysiology, cell biology, viral tracings and 2-photon calcium imaging to investigate the anatomical and functional organization of the neuronal circuits engaged in chronic pain, including those in the dorsal horn, but also their dynamics and the conditions of their recruitment.

Journal articles

2024

ref_biblio: Nathan Moreau, Cédric Peirs, Radhouane Dallel, Yves Boucher. Spécificités de la douleur neuropathique oro-faciale. Médecine/Sciences, 2024, 40 (1), pp.64 - 71. ⟨10.1051/medsci/2023197⟩. ⟨hal-04438162⟩
Accès au texte intégral et bibtex

ref_biblio: Nathan Moreau, Cédric Peirs, Radhouane Dallel, Yves Boucher. Spécificités de la douleur neuropathique oro-faciale. Médecine/Sciences, 2024, 40 (1), pp.64-71. ⟨10.1051/medsci/2023197⟩. ⟨hal-04433402⟩
Accès au texte intégral et bibtex

2022

ref_biblio: Sylvain Mathieu, Martin Soubrier, Cedric Peirs, Laurent-Emmanuel Monfoulet, Yves Boirie, et al.. A Meta-Analysis of the Impact of Nutritional Supplementation on Osteoarthritis Symptoms. Nutrients, 2022, 14 (8), pp.1607. ⟨10.3390/nu14081607⟩. ⟨hal-03736597⟩
Accès au texte intégral et bibtex

2021

ref_biblio: Cedric Peirs, Sean-Paul G G Williams, Xinyi Zhao, Cynthia M Arokiaraj, David W Ferreira, et al.. Mechanical Allodynia Circuitry in the Dorsal Horn Is Defined by the Nature of the Injury. Neuron, 2021, 109, pp.1 - 18. ⟨10.1016/j.neuron.2020.10.027⟩. ⟨inserm-03001339⟩
Accès au texte intégral et bibtex

2020

ref_biblio: Cedric Peirs, Radhouane Dallel, Andrew J Todd. Recent advances in our understanding of the organization of dorsal horn neuron populations and their contribution to cutaneous mechanical allodynia. Journal of Neural Transmission, 2020, 127 (4), pp.505 - 525. ⟨10.1007/s00702-020-02159-1⟩. ⟨hal-04487368⟩
Accès au texte intégral et bibtex

ref_biblio: Cedric Peirs, Radhouane Dallel, Andrew J Todd. Recent advances in our understanding of the organization of dorsal horn neuron populations and their contribution to cutaneous mechanical allodynia. Journal of Neural Transmission, 2020, 127 (4), pp.505-525. ⟨10.1007/s00702-020-02159-1⟩. ⟨inserm-02701538⟩
Accès au texte intégral et bibtex

2016

ref_biblio: Cedric Peirs, Rebecca Seal. Neural circuits for pain: recent advances and current views. Science, 2016, 354 (6312), pp.578-584. ⟨10.1126/science.aaf8933⟩. ⟨hal-04412766⟩
Accès au texte intégral et bibtex

ref_biblio: Cedric Peirs, Nathalie Bourgois, Alain Artola, Radhouane Dallel. PKCγ Interneurons Mediate C-Fiber-Induced Orofacial Secondary Static Mechanical Allodynia, but not C-Fiber-Induced Nociceptive Behavior. Anesthesiology, 2016, 124 (5), pp.1136-1152. ⟨10.1097/ALN.0000000000001000⟩. ⟨hal-04412813⟩
Accès au texte intégral et bibtex

2015

ref_biblio: Cristina Alba-Delgado, Corinne El Khoueiry, Cédric Peirs, Radhouane Dallel, Alain Artola, et al.. Subpopulations of PKCγ interneurons within the medullary dorsal horn revealed by electrophysiologic and morphologic approach. Pain, 2015, 156 (9), pp.1714-1728. ⟨10.1097/j.pain.0000000000000221⟩. ⟨hal-04326290⟩
Accès au bibtex

ref_biblio: Cedric Peirs, Sean-Paul G Williams, Xinyi Zhao, Claire E Walsh, Jeremy Y Gedeon, et al.. Dorsal Horn Circuits for Persistent Mechanical Pain. Neuron, 2015, 87 (4), pp.797 - 812. ⟨10.1016/j.neuron.2015.07.029⟩. ⟨hal-04400758⟩
Accès au texte intégral et bibtex

ref_biblio: Cedric Peirs, Rebecca Seal. Targeting Toll-like receptors to treat chronic pain. Nature Medicine, 2015, 21 (11), pp.1251-1252. ⟨10.1038/nm.3986⟩. ⟨hal-04400819⟩
Accès au texte intégral et bibtex

2014

ref_biblio: Cédric Peirs, Sudarshan Patil, Rabia Bouali-Benazzouz, Alain Artola, Marc Landry, et al.. Protein kinase C gamma interneurons in the rat medullary dorsal horn: distribution and synaptic inputs of these neurons, and subcellular localization of the enzyme. Journal of Comparative Neurology, 2014, 522 (2), pp.393-413. ⟨10.1002/cne.23407⟩. ⟨hal-04412846⟩
Accès au texte intégral et bibtex

2011

ref_biblio: Loïs S Miraucourt, Cédric Peirs, Radhouane Dallel, Daniel L Voisin. Glycine inhibitory dysfunction turns touch into pain through astrocyte-derived D-serine. Pain, 2011, 152 (6), pp.1340 - 1348. ⟨10.1016/j.pain.2011.02.021⟩. ⟨hal-04412880⟩
Accès au bibtex

Conference papers

2023

ref_biblio: Cedric Peirs. Plasticity of sensory processing by spinal dorsal horn neurons after neuropathy. Montreal Conference on Pain Circuit, Jul 2023, Montréal Québec, Canada. ⟨hal-04412400⟩
Accès au bibtex

ref_biblio: Cedric Peirs. Microcircuits underlying inflammatory versus neuropathic pain. NeuroFrance 2023, May 2023, Lyon, France. ⟨hal-04412439⟩
Accès au bibtex

ref_biblio: Cedric Peirs. Advances in signaling and treatments of inflammatory pain syndromes. NeuroFrance 2023, May 2023, Lyon, France. ⟨hal-04412407⟩
Accès au bibtex

2022

ref_biblio: Cedric Peirs. Understanding dorsal horn circuits mediating mechanical allodynia. McGill University seminar series, Sep 2022, Montréal, Canada. ⟨hal-04412446⟩
Accès au bibtex

2021

ref_biblio: Cedric Peirs. Analysis of dorsal horn pain circuits through two-photon imaging. 6th symposium of microscopy of Clermont-Ferrand, Oct 2021, Clermont-Ferrand, France. ⟨hal-04412459⟩
Accès au bibtex

ref_biblio: Cedric Peirs. Heterogeneity of Pain within the Dorsal Horn. Universitätsklinikum Aachen - Physiologisches Kolloquium, Jul 2021, Aachen, Germany. ⟨hal-04412464⟩
Accès au bibtex

ref_biblio: Cedric Peirs. Mare de souffrir, mais que font les chercheurs ?!. Semaine du cerveau 2021, Mar 2021, Clermont-Ferrand, France. ⟨hal-04412587⟩
Accès au bibtex

ref_biblio: Cedric Peirs. Heterogeneity in Dorsal Horn Circuits that Mediate Persistent Pain. Pain 2021 Workshop: Genetic Interrogation of Spinal Cord Circuits, Jun 2021, Houston, United States. ⟨hal-04412468⟩
Accès au bibtex

ref_biblio: Cedric Peirs. Pain in the dorsal horn: network or circuits?. International Workshop on Chronic Pain and Itch: Mechanisms and Circuits, Oct 2021, Alicante, Spain. ⟨hal-04412453⟩
Accès au bibtex

2019

ref_biblio: Cedric Peirs. Plus bête qu’hier et bien moins que demain. Semaine du cerveau 2019, Mar 2019, Clermont-Ferrand, France. ⟨hal-04412590⟩
Accès au bibtex

2018

ref_biblio: Cedric Peirs. Distinct neuronal circuits to turn touch into pain. Mini – Symposium IGF: Neuronal Circuits in Pain & Development, Nov 2018, Montpellier, France. ⟨hal-04412488⟩
Accès au bibtex

ref_biblio: Cedric Peirs. Optogénétique et chémogénétique pour contrôler la douleur. Workshop Analgesia, Apr 2018, Clermont-Ferrand, France. ⟨hal-04412507⟩
Accès au bibtex

ref_biblio: Cedric Peirs. Unravelling Spinal Circuits Underlying Chronic Pain. The 17th world congress on pain, Sep 2018, Boston, United States. ⟨hal-04412501⟩
Accès au bibtex

ref_biblio: Cedric Peirs. Distinct neuronal circuits mediate mechanical allodynia. Workshop Neurex, Oct 2018, Strasbourg, France. ⟨hal-04412495⟩
Accès au bibtex

ref_biblio: Cedric Peirs. Identifying the Central Circuits for Mechanical Pain. XIVth National Symposium of the French Consortium of Pain Research, Mar 2018, Toulouse, France. ⟨hal-04412642⟩
Accès au bibtex

ref_biblio: Cedric Peirs. Pain Circuits: Newly Discovered Networks Underlie Pain Symptoms And Dimensions. The 17th world congress on pain, Sep 2018, Boston, United States. ⟨hal-04412687⟩
Accès au bibtex

2017

ref_biblio: Cedric Peirs. The Neuronal Circuit that Turns Touch into Pain. Les Mardi du GReD, Nov 2017, Clermont-Ferrand, France. ⟨hal-04412514⟩
Accès au bibtex

ref_biblio: Cedric Peirs. Spinal cord networks underlying mechanical allodynia. French Society for Research and Treatment of Pain, Nov 2017, Nice, France. ⟨hal-04412516⟩
Accès au bibtex

ref_biblio: Cedric Peirs. The Spinal Cord Circuits for Chronic Pain. Neurofrance 2017, May 2017, Bordeaux, France. ⟨hal-04412524⟩
Accès au bibtex

2014

ref_biblio: Cedric Peirs. The Spinal Cord Circuit that Turns Touch into Pain. Postdoc-to-Postdoc, Dec 2014, Pittsburgh, United States. ⟨hal-04412532⟩
Accès au bibtex

ref_biblio: Cedric Peirs. A Critical Role for the Vesicular Glutamate Transporter 3 in Central Mechanical Pain Circuits. Neurobiology of Pain and Itch, Apr 2014, San Francisco, United States. ⟨hal-04412538⟩
Accès au bibtex

2012

ref_biblio: Cedric Peirs. Segmental mechanisms of trigeminal mechanical allodynia: the role of Reactive Oxygen Species (ROS). 8th Annual Symposium of the INSERM research network on Pain, Mar 2012, Clermont-Ferrand, France. ⟨hal-04412550⟩
Accès au bibtex

ref_biblio: Cedric Peirs. How can touch turn into pain: PKCγ neurons. Doctoral school symposium, May 2012, Clermont-Ferrand, France. ⟨hal-04412546⟩
Accès au bibtex

2011

ref_biblio: Cedric Peirs. Between touch and pain: PKCγ interneurons. 7th Research Day, Dec 2011, Clermont-Ferrand, France. ⟨hal-04412557⟩
Accès au bibtex

2009

ref_biblio: Cedric Peirs. Does the RLX3/RXFP3 system in the lateral hypothalamic area (LHA) influence circadian food anticipatory activity (FAA) in rats?. Relaxin symposium, May 2009, Melbourne, Australia. ⟨hal-04412564⟩
Accès au bibtex

Poster communications

2024

ref_biblio: A Gilbert, L Rabiller, L Miraucourt, M Georgiopoulos, I Colmegna, et al.. Evaluating a novel target in the treatment of osteoarthritis pain. McGill Pain Day, Jan 2024, Montréal, Canada. ⟨hal-04424974⟩
Accès au bibtex

2023

ref_biblio: A Gilbert, L Miraucourt, M Georgiopoulos, I Colmegna, J Ouellet, et al.. Evaluation of TACAN as a new target for treating osteoarthritis pain. 9th Mediterranean Neuroscience Society (MNS) Conference, Oct 2023, Carthage, Tunisia. ⟨hal-04412913⟩
Accès au bibtex

ref_biblio: A Gilbert, L Rabiller, L Miraucourt, M Georgiopoulos, I Colmegna, et al.. Evaluation of TACAN as a new target for treating osteoarthritis pain. McGill Pain Day, Jan 2023, Montréal, Canada. ⟨hal-04412927⟩
Accès au bibtex

2022

ref_biblio: A Negm, F Gabrielli, R Dallel, Cedric Peirs. Revealing dorsal horn circuits through 2-photon calcium imaging. The 2022 world congress on pain, Sep 2022, Toronto, Canada. ⟨hal-04412943⟩
Accès au bibtex

2021

ref_biblio: J Makhoul, S Mountadem, A Artola, R Dallel, Cedric Peirs. How Does Kir4.1 turn Touch into Pain?. 24th Day of doctoral school SVSAE, May 2021, Clermont-Ferrand, France. ⟨hal-04412957⟩
Accès au bibtex

ref_biblio: A Negm, F Gabrielli, J Makhoul, A Artola, R Dallel, et al.. Revealing dorsal horn circuits through 2-photon calcium imaging. International Workshop on Chronic Pain and Itch: Mechanisms and Circuits, Oct 2021, Alicante, Spain. ⟨hal-04412950⟩
Accès au bibtex

2020

ref_biblio: S Mountadem, Cedric Peirs, K Herault, M Antri, R Dallel. Astroglial Kir4.1 ion channel deficit underlies inflammatory mechanical allodynia. French Society for Research and Treatment of Pain, Mar 2020, Bordeaux, France. ⟨hal-04412965⟩
Accès au bibtex

2019

ref_biblio: J Makhoul, L Poncet-Megemont, K Herault, A Descheemaeker, F Gabrielli, et al.. Identifying Central Circuits for Mechanical Pain. I-site CAP20-25 - Séminaire annuel du Challenge 3, Jan 2019, Clermont-Ferrand, France. ⟨hal-04412977⟩
Accès au bibtex

2017

ref_biblio: Cedric Peirs, Sp Williams, X Zhao, Ce Walsh, J Gedeon, et al.. The Spinal Cord Circuits For Chronic Pain. Neurofrance 2017, May 2017, Bordeaux, France. ⟨hal-04413001⟩
Accès au bibtex

ref_biblio: Cedric Peirs, X Zhao, Sp Williams, J Gedeon, Rp Seal. Neural Circuits for Mechanical Allodynia in the Spinal Cord Dorsal Horn. Annual Meeting Society for Neuroscience, Nov 2017, Washington, United States. ⟨hal-04412984⟩
Accès au bibtex

2015

ref_biblio: J Gedeon, Cedric Peirs, Sp Williams, X Zhao, P Marell, et al.. Identification of Excitatory Neuron Populations that Form the Dorsal Horn Mechanical Pain Circuit. Midwest/Great Lakes Undergraduate Research Symposium in Neuroscience, Oct 2015, Colombus, United States. ⟨hal-04413025⟩
Accès au bibtex

ref_biblio: Cedric Peirs, Sp Williams, X Zhao, J Gedeon, Rp Seal. Identification of Excitatory Neuron Populations that Form the Dorsal Horn Mechanical Pain Circuit. Annual Meeting Society for Neuroscience, Oct 2015, Chicago, United States. ⟨hal-04413028⟩
Accès au bibtex

ref_biblio: Cedric Peirs, Sp Williams, X Zhao, J Gedeon, Rp Seal. Identification of Excitatory Neuron Populations that Form the Dorsal Horn Mechanical Pain Circuit. Data and Dine, May 2015, Pittsburgh, United States. ⟨hal-04413009⟩
Accès au bibtex

ref_biblio: Cedric Peirs, Sp Williams, X Zhao, J Gedeon, P Marell, et al.. Identification of Excitatory Neuron Populations that Form the Dorsal Horn Mechanical Pain Circuit. Barriers to Translation of Pain Research, Jun 2015, Pittsburgh, United States. ⟨hal-04413019⟩
Accès au bibtex

ref_biblio: X Zhao, Cedric Peirs, Sp Williams, Rp Seal. Chemogenetic approach to study central mechanical pain circuits. 4th Annual Joint Scientific Pitt-Tsinghua Symposium, May 2015, Pittsburgh, United States. ⟨hal-04413016⟩
Accès au bibtex

2014

ref_biblio: Cedric Peirs, Sp Williams, Ce Walsh, Z Liu, Ne Cagle, et al.. A Critical Role for the Vesicular Glutamate Transporter 3 in Central Mechanical Pain Circuits. Annual Meeting Society for Neuroscience, Nov 2014, Washington, United States. ⟨hal-04413030⟩
Accès au bibtex

2012

ref_biblio: Cedric Peirs, S Patil, M Landry, A Artola, R Dallel. Organization and anatomical properties of Protein Kinase C gamma interneurons in the medullary dorsal horn. 8th FENS Forum of Neuroscience, Jul 2012, Barcelona, Spain. ⟨hal-04413035⟩
Accès au bibtex

2011

ref_biblio: Cedric Peirs, A Descheemaeker, A Artola, R Dallel. How can touch become pain: the short-circuit PKCγ. Doctoriales 2011, Jun 2011, Saint-Nectaire, France. ⟨hal-04413042⟩
Accès au bibtex

ref_biblio: Cedric Peirs, N Pham-Dang, A Artola, R Dallel. Activation of protein kinase C in the medullary dorsal horn produces mechanical hypersensitivity through superficial laminae nociceptive-specific NK1 receptor-negative neurons. 10th Colloque of the French Neuroscience Society, May 2011, Marseille, France. ⟨hal-04413053⟩
Accès au bibtex

Theses

2012

ref_biblio: Cédric Peirs. Mécanismes segmentaires de l'allodynie mécanique statique trigéminale : rôle des dérivés réactifs de l'oxygène (ROS), de la désinhibition GABAergique et des interneurones PKCγ. Neurosciences [q-bio.NC]. Université d'Auvergne - Clermont-Ferrand I, 2012. Français. ⟨NNT : 2012CLF1DD03⟩. ⟨tel-04498186⟩
Accès au texte intégral et bibtex