Denis ARDID

UMR 1107 INSER/UCA Neuro-Dol
Facultés de Médecine et Pharmacie
Place Henri Dunant
63001 Clermont-Ferrand
FRANCE

28 place Henri Dunant
63001 Clermont-Ferrand Cedex 1
France

Pr. Denis ARDID

Professor
TEAM 1 (J. BUSSEROLLES), TEAM 1 microbiota axis

denis.ardid@-Code to remove to avoid SPAM-uca.fr
+33 4 73 17 82 39

Denis ARDID is a professor in physiology and pharmacology. He was at the head of the TEAM 1 from 2010 to 2023. He started his research by decifering the mechanisms of action of antidepressant in the treatment of pain. He worked also on preclinical models of pain trying to improve its measure in rodent. From several years, he is focused on visceral pain, mainly colonic, and its modulation by microbiota.

Journal articles

2023

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Sandie Gervason, Mathieu Meleine, Stéphane Lolignier, Maëva Meynier, Valentine Daugey, et al.. Antihyperalgesic properties of gut microbiota: Parabacteroides distasonis as a new probiotic strategy to alleviate chronic abdominal pain. Pain, 2023, ⟨10.1097/j.pain.0000000000003075⟩. ⟨hal-04316524⟩
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2022

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Lauriane Delay, Julie Barbier, Youssef Aissouni, Alexandra Jurczak, Ludivine Boudieu, et al.. Tyrosine kinase type A–specific signalling pathways are critical for mechanical allodynia development and bone alterations in a mouse model of rheumatoid arthritis. Pain, 2022, 163 (7), pp.e837-e849. ⟨10.1097/j.pain.0000000000002492⟩. ⟨hal-04316536⟩
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Geoffroy Mallaret, Amandine Lashermes, Mathieu Meleine, Ludivine Boudieu, Julie Barbier, et al.. Involvement of toll-like receptor 5 on mouse model of colonic hypersensitivity induced by neonatal maternal separation. World Journal of Gastroenterology, 2022, 28 (29), pp.3903-3916. ⟨10.3748/wjg.v28.i29.3903⟩. ⟨hal-03987265⟩
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Maëva Meynier, Elodie Baudu, Nathalie Rolhion, Manon Defaye, Marjolène Straube, et al.. AhR/IL-22 pathway as new target for the treatment of post-infectious irritable bowel syndrome symptoms. Gut microbes, 2022, 14 (1), pp.1-21. ⟨10.1080/19490976.2021.2022997⟩. ⟨hal-03555153⟩
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https://uca.hal.science/hal-03555153/file/2022_Meynier_Gut_Microbes.pdf BibTex

2021

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Jessica Delorme, Célian Bertin, Noémie Delage, Alain Eschalier, Denis Ardid, et al.. Prevalence of chronic pain in opioid-maintained patients using the capture–recapture method: a nationwide population-based study. Pain, 2021, 162 (1), pp.195-202. ⟨10.1097/j.pain.0000000000002011⟩. ⟨hal-04316546⟩
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2020

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Tanguy Chaumette, Lauriane Delay, Julie Barbier, Ludivine Boudieu, Youssef Aissouni, et al.. c-Jun/p38MAPK/ASIC3 pathways specifically activated by nerve growth factor through TrkA are crucial for mechanical allodynia development. Pain, 2020, pp.1. ⟨10.1097/j.pain.0000000000001808⟩. ⟨hal-02464551⟩
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https://hal.science/hal-02464551/file/PAIN-D-19-00901_R2.pdf BibTex
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Manon Defaye, Sandie Gervason, Christophe Altier, Jean-Yves Berthon, Denis Ardid, et al.. Microbiota: a novel regulator of pain. Journal of Neural Transmission, 2020, 127 (4), pp.445-465. ⟨10.1007/s00702-019-02083-z⟩. ⟨hal-03036258⟩
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Manon Defaye, Céline Nourrisson, Elodie Baudu, Amandine Lashermes, Maeva Meynier, et al.. Fecal dysbiosis associated with colonic hypersensitivity and behavioral alterations in chronically Blastocystis-infected rats. Scientific Reports, 2020, 10 (1), pp.9146. ⟨10.1038/s41598-020-66156-w⟩. ⟨inserm-02884871⟩
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https://inserm.hal.science/inserm-02884871/file/s41598-020-66156-w.pdf BibTex

2019

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David André Barrière, Al Mahdy Hamieh, Ricardo Magalhães, Amidou Traore, Julie Barbier, et al.. Structural and functional alterations in the retrosplenial cortex following neuropathic pain. Pain, 2019, 160 (10), pp.2241-2254. ⟨10.1097/j.pain.0000000000001610⟩. ⟨hal-04327523⟩
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Celian Bertin, Jessica Delorme, Marie Riquelme, Hélène Peyrière, Alain Eschalier, et al.. Toward a Triadic Approach to Craving in Addictive Disorders. Harvard Review of Psychiatry, 2019, 27 (5), pp.326-331. ⟨10.1097/HRP.0000000000000225⟩. ⟨hal-02384764⟩
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Célian Bertin, Jessica Delorme, Marie Riquelme, Hélène Peyriere, Georges Brousse, et al.. Risk assessment of using off‐label morphine sulfate in a population‐based retrospective cohort of opioid‐dependent patients. British Journal of Clinical Pharmacology, 2019, 86 (12), pp.2338-2348. ⟨10.1111/bcp.14082⟩. ⟨hal-02325453⟩
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Ludivine Boudieu, Sarah Mountadem, Amandine Lashermes, Mathieu Meleine, Lauriane Ulmann, et al.. Blocking α2δ-1 Subunit Reduces Bladder Hypersensitivity and Inflammation in a Cystitis Mouse Model by Decreasing NF-kB Pathway Activation. Frontiers in Pharmacology, 2019, 10, pp.133. ⟨10.3389/fphar.2019.00133⟩. ⟨hal-02324745⟩
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https://hal.science/hal-02324745/file/fphar-10-00133.pdf BibTex
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C. Chenaf, J.-L. Kaboré, J. Delorme, Bruno Pereira, A. Mulliez, et al.. Prescription opioid analgesic use in France: Trends and impact on morbidity-mortality. European Journal of Pain, 2019, 23 (1), pp.124-134. ⟨10.1002/ejp.1291⟩. ⟨hal-02323031⟩
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Nicolas Kerckhove, Julien Scanzi, Bruno Pereira, Denis Ardid, Michel Dapoigny. Effectiveness and safety of 5% lidocaine-medicated plaster on localized neuropathic pain after knee surgery: a randomized, double-blind controlled trial. Pain, 2019, 160 (5), pp.1186-1195. ⟨10.1097/j.pain.0000000000001502⟩. ⟨hal-04257309⟩
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Elodie Picard, Frédéric Antonio Carvalho, Francina Agosti, Emmanuel Bourinet, Denis Ardid, et al.. Inhibition of Cav3.2 calcium channels: A new target for colonic hypersensitivity associated with low‐grade inflammation. British Journal of Pharmacology, 2019, 176 (7), pp.950-963. ⟨10.1111/bph.14608⟩. ⟨hal-04317223⟩
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https://hal.science/hal-04317223/file/British%20J%20Pharmacology%20-%202019%20-%20Picard%20-%20Inhibition%20of%20Cav3%202%20calcium%20channels%20A%20new%20target%20for%20colonic%20hypersensitivity%281%29.pdf BibTex

2018

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Chenaf Chouki, Jessica Delorme, Noémie Delage, Denis Ardid, Alain Eschalier, et al.. Prevalence of chronic pain with or without neuropathic characteristics in France using the capture-recapture method: a population-based study.. Pain, 2018, 159 (11), pp.2394-2402. ⟨10.1097/j.pain.0000000000001347⟩. ⟨hal-01926185⟩
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Manon Defaye, Céline Nourrisson, Elodie Baudu, Ivan Warwzyniak, Virginie Bonnin, et al.. Efficient and reproducible experimental infections of rats with Blastocystis spp.. PLoS ONE, 2018, 13 (11), pp.1-15. ⟨10.1371/journal.pone.0207669⟩. ⟨hal-01931278⟩
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https://uca.hal.science/hal-01931278/file/2018_Delaye_Plos_One.pdf BibTex
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Jessica Delorme, Chouki Chenaf, Célian Bertin, Marie Riquelme, Alain Eschalier, et al.. Chronic Pain Opioid-Maintained Patients Receive Less Analgesic Opioid Prescriptions. Frontiers in Psychiatry, 2018, 9, pp.335. ⟨10.3389/fpsyt.2018.00335⟩. ⟨hal-04317238⟩
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https://hal.science/hal-04317238/file/fpsyt-09-00335.pdf BibTex

2017

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Youssef Aissouni, Abderrahim El Guerrab, Al Mahdy Hamieh, Jérémy Ferrier, Maryse Chalus, et al.. Acid-Sensing Ion Channel 1a in the amygdala is involved in pain and anxiety-related behaviours associated with arthritis. Scientific Reports, 2017, 7 (1), pp.43617. ⟨10.1038/srep43617⟩. ⟨hal-04317279⟩
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https://hal.science/hal-04317279/file/srep43617.pdf BibTex
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Amandine Dupuis, Anne-Sophie Wattiez, Jérémy Pinguet, Damien Richard, Frédéric Libert, et al.. Increasing spinal 5-HT 2A receptor responsiveness mediates anti-allodynic effect and potentiates fluoxetine efficacy in neuropathic rats. Evidence for GABA release. Pharmacological Research, 2017, 118, pp.93-103. ⟨10.1016/j.phrs.2016.09.021⟩. ⟨hal-04317276⟩
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Nicolas Kerckhove, Julien Scanzi, Bruno Pereira, Denis Ardid, Michel Dapoigny. Assessment of the effectiveness and safety of ethosuximide in the treatment of abdominal pain related to irritable bowel syndrome – IBSET: protocol of a randomised, parallel, controlled, double-blind and multicentre trial. BMJ Open, 2017, 7 (7), pp.e015380. ⟨10.1136/bmjopen-2016-015380⟩. ⟨hal-04317249⟩
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Amandine Lashermes, Ludivine Boudieu, Julie Barbier, Benoit Sion, Agathe Gelot, et al.. Adherent-Invasive E. coli enhances colonic hypersensitivity and P2X receptors expression during post-infectious period. Gut microbes, 2017, 9 (1), pp.26-37. ⟨10.1080/19490976.2017.1361091⟩. ⟨hal-04317240⟩
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2016

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Mathieu Meleine, Ludivine Boudieu, Agathe Gelot, Emilie Muller, Amandine Lashermes, et al.. Comparative effects of alpha 2 delta-1 ligands in mouse models of colonic hypersensitivity. World Journal of Gastroenterology, 2016, 22 (31), pp.7111-7123. ⟨10.3748/wjg.v22.i31.7111⟩. ⟨hal-02636301⟩
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https://hal.inrae.fr/hal-02636301/file/2016_Meleine_World%20Journal%20of%20Gastroenterology_1.pdf BibTex

2013

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Amaury François, Nicolas Kerckhove, Mathieu Meleine, Abdelkrim Alloui, Christian Barrère, et al.. State-dependent properties of a new T-type calcium channel blocker enhance CaV3.2 selectivity and support analgesic effects. Pain, 2013, 154 (2), pp.283-293. ⟨10.1016/j.pain.2012.10.023⟩. ⟨hal-02370536⟩
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2012

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Julien Matricon, Agathe Gelot, Monique Etienne, Michel Lazdunski, Emilie Muller, et al.. Spinal cord plasticity and acid‐sensing ion channels involvement in a rodent model of irritable bowel syndrome. European Journal of Pain, 2012, 15 (4), pp.335-343. ⟨10.1016/j.ejpain.2010.08.005⟩. ⟨hal-04320320⟩
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2007

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Christel Rousseaux, Xavier Thuru, Agathe Gelot, Nicolas Barnich, Christel Neut, et al.. Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors. Nature Medicine, 2007, 13 (1), pp.35-37. ⟨10.1038/nm1521⟩. ⟨hal-02667010⟩
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Conference papers

2020

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Maeva Meynier, Elodie Baudu, Nicolas Barnich, Denis Ardid, Jean-Marc Chatel, et al.. Tryptophan derivatives effects via the AhR signaling pathway modulation on host disturbances after a Citrobacter rodentium infection. CELL SYMPOSIA, May 2020, PARIS, France. ⟨hal-03045712⟩
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Poster communications

2021

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Sandie Gervason, Edith Filaire, Mathieu Meleine, Denis Ardid, Jean-Yves Berthon, et al.. Strict anaerobic bacteria involvement in gut-brain axis: A novel regulator of visceral pain and well-being. Federation of Neurgastroenterology & Motility, Apr 2021, adélaïde, Australia. 32, 2020. ⟨hal-03038507⟩
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2020

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Maeva Meynier, Elodie Baudu, Nicolas Barnich, Denis Ardid, J.M. Chatel, et al.. Effects of tryptophan derivatives via the AHR/Il22 signaling pathway modulation on host disturbances in post citrobacter rodentium infection model mimicking irritable bowel syndrome. UEGW 2020, Oct 2020, AMSTERDAM, Netherlands. ⟨hal-03046872⟩
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2019

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Florian Jacquot, Julie Barbier, Denis Ardid, Fabien Marchand. Peripheral ASIC3 activation by lysophosphatidyl-choline induced chronic joint pain and associated anxiety in mice. Neuroscience 2019, Congress of Society of Neuroscience, Oct 2019, CHICAGO, United States. ⟨hal-02363978⟩
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