TEAM 1 collaborations

Local collaborations: We have a strong and long standing collaboration with the Institute of Chemistry of Clermont-Ferrand (UMR Sigma CNRS- Clermont Auvergne University), particularly with the COM team (“Chimie Organique et Médicinale”) headed by Claude TAILLEFUMIER. One of the team’s subgroup is dedicated to the development of new analgesic drugs, the CESMA (“Conception et Synthèse de Molécules Antalgiques”). CESMA is a founding member of the Analgesia Partnership cluster that became the Analgesia Institute. We developed a close and fruitful collaboration that resulted in the synthesis of several patented drugs, some of which being under advanced preclinical development. Within the cluster, we collaborate with all academic and industrial members relevant to our interests and needs. We also worked closely with the Clinical Investigation Center (some members of the team are also members of the CIC, Gisèle PICKERING, the coordinator, and Claude DUBRAY) and with the Pain Clinic (headed by Nicolas AUTHIER) for clinical studies in pain patients or healthy volunteers. We also collaborate with clinicians involved in pain management in the regional cancer center or various clinical departments of the university hospital. Sustained collaborations were established with others local INSERM or CNRS units (GReD, IMTV, M2iSH, LMGE), either fully integrated to research projects or for specific technical needs (e.g. in vitro and/or in vivo imaging, microbiota analysis). A 4 years old collaboration was initiated with INNOPAIN and from September 2019, we will have a technician (Julien SCHOPP) of this company in our lab to perform electrophysiological and in vivo studies. Finally, we have initiated a collaboration with the private company GREENTECH for the development of probiotics in the treatment of sensory disorders. We have a CIFRE PhD student (Sandie GERVASON) co-supervised by Frédéric CARVALHO (member of our team) and Edith FILAIRE (from GREENTECH).

National collaborations: At the national level, we have a close and sustained collaboration with the Institute of Functional Genomics (UMR CNRS-INSERM-Université de Montpellier), particularly with the teams supervised by J.-P. Pin, E. Bourinet and P. Marin; with the Institute of Molecular and Cellular Pharmacology (UMR CNRSUniversité de Nice Sophia Antipolis), particularly with the teams supervised by E. Lingueglia and F. Lesage; with the “Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille” (UMR CNRS-Aix-MarseilleUniversité); with N. Prevarskaya‘s group (INSERM U1003, Université des Sciences et Technologies de Lille, Villeneuve d’Ascq) and with Pr Odile Sergent (Stress, Membrane and signaling, IRSET Institute, Rennes). We are also developing collaborations 1) inside the French neuro-gastroenterology network to initiate a translational research program implying the use of colonic biopsies and/or the creation of a colonic biopsy bank and 2) with several pain clinics through multicentric studies. We also work together with the ProbiHôte team (P. Langella) of the MICALIS institute of INRA in Jouy-en Josas and with the ToxAlim team (V. Theodorou, N Cenac) of the INRA of Toulouse regarding the development of probiotics for the treatment of chronic colonic pain.

International collaborations: Internationally we have, during the past five years, developed several collaborations that resulted in joint publications: Center for Inflammation, Immunity, and Infection and Department of Biology, Georgia State University, Atlanta, USA (A. Gewirtz); Department of the Medicine Laboratory, Lund University, Sweden (E. Hogesstat, P. Zygmunt); Laboratory of Neurobiology, Department of Biology, Faculty of Chemistry and Biology, University of Santiago of Chile, Santiago, Chile (T. Pelissier); Instituto de Investigaciones en Medicina Traslacional, Austral University, Argentina (Pablo Brumovsky); Laboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium (C. Ledent); Neurorestauration group, Wolfson centre for Age Related Diseases, King’s College London, London, UK (S.B. McMahon). More recently, other collaborations were developed: Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA (D. Chetkovich), Department of Medicinal Chemistry, Jagiellonian University Medical College, Kraków, Poland (P. Zajdel), Molecular Pain research, Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden (C.I. Svensson),  Institute of Analytical and Bioanalytical Chemistry, Ulm University, Germany and the laboratoire des substances bioactives du centre de biotechnologie de Borj Cédria, Tunisie.